Study Finds Most Common Statin Side-Effects Unrelated to Medication
A comprehensive review of evidence has revealed that nearly all side-effects listed on statin labels are not caused by the medication itself. The study, published in the Lancet, analyzed 19 randomized controlled trials involving over 124,000 people and found that only four out of 66 commonly listed side-effects - liver test changes, minor liver abnormalities, urine changes, and tissue swelling - were supported by strong evidence.
In contrast, the majority of these side-effects, including memory problems, depression, sleep disturbances, nerve damage leading to tingling in the hands and feet, among others, showed no correlation with statin use. The study's findings suggest that the risk of most listed side-effects is minimal, while the benefits of taking statins far outweigh the potential harms.
The results have significant implications for patients considering taking statins, as it provides reassurance that the commonly experienced events associated with these medications are not caused by the medication itself. According to the study's lead author, Christina Reith, "What we were able to show reliably was that statins did not make these commonly experienced events occur more often."
The updated labels should reflect this new evidence, allowing patients and doctors to make more informed choices about statin therapy. As Prof Sir Rory Collins noted, "Now that we know that statins do not cause the majority of side-effects listed in package leaflets, statin information requires rapid revision to help patients and doctors make better-informed health decisions."
The study's findings should come as welcome news for millions of people worldwide who have been put off taking statins due to safety concerns. As Prof Victoria Tzortziou Brown said, "Those considering taking statins should be reassured by this comprehensive study... The risk for most people is low."
A comprehensive review of evidence has revealed that nearly all side-effects listed on statin labels are not caused by the medication itself. The study, published in the Lancet, analyzed 19 randomized controlled trials involving over 124,000 people and found that only four out of 66 commonly listed side-effects - liver test changes, minor liver abnormalities, urine changes, and tissue swelling - were supported by strong evidence.
In contrast, the majority of these side-effects, including memory problems, depression, sleep disturbances, nerve damage leading to tingling in the hands and feet, among others, showed no correlation with statin use. The study's findings suggest that the risk of most listed side-effects is minimal, while the benefits of taking statins far outweigh the potential harms.
The results have significant implications for patients considering taking statins, as it provides reassurance that the commonly experienced events associated with these medications are not caused by the medication itself. According to the study's lead author, Christina Reith, "What we were able to show reliably was that statins did not make these commonly experienced events occur more often."
The updated labels should reflect this new evidence, allowing patients and doctors to make more informed choices about statin therapy. As Prof Sir Rory Collins noted, "Now that we know that statins do not cause the majority of side-effects listed in package leaflets, statin information requires rapid revision to help patients and doctors make better-informed health decisions."
The study's findings should come as welcome news for millions of people worldwide who have been put off taking statins due to safety concerns. As Prof Victoria Tzortziou Brown said, "Those considering taking statins should be reassured by this comprehensive study... The risk for most people is low."