New Study Reveals Dark Side of Mounjaro: Weight Loss Jab Loses Its Effectiveness After Stopping Use
A recent study has shed light on a concerning trend associated with the popular weight-loss medication Mounjaro. Researchers found that individuals who discontinue using tirzepatide, an active ingredient in Mounjaro, not only regain weight but also experience a reversal of other health benefits they had achieved while taking the medication.
The study, which involved over 300 participants with obesity or overweight issues, revealed that within a year of stopping tirzepatide, nearly three-quarters of those who had lost at least 10% of their body weight initially regained 25% or more of what they had lost. The researchers also found that the extent of weight regain was correlated with the degree to which other health markers – such as blood pressure, waist circumference, and levels of "bad" cholesterol – reverted to baseline values.
Experts say this is not a surprising finding, given the well-established link between excess weight and elevated blood pressure, impaired glucose control, and other cardiometabolic risks. Dr. Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow, noted that when weight loss achieved through medication is regained, these risk factors tend to increase in proportion to the speed and extent of weight regain.
The study's findings have significant implications for the long-term management of obesity and related health conditions. While Mounjaro has shown promise in helping people lose an average of 20% of their body weight over 72 weeks, its effects are short-lived once use is discontinued. Dr. Jane Ogden, an emeritus professor at the University of Surrey, warned that relying on weight-loss medications without developing sustainable lifestyle habits can lead to a reversal of health benefits.
The study's authors emphasized the importance of long-term maintenance of weight reduction through a combination of lifestyle intervention and medication management to sustain cardiometabolic benefits and improved health-related quality of life.
A recent study has shed light on a concerning trend associated with the popular weight-loss medication Mounjaro. Researchers found that individuals who discontinue using tirzepatide, an active ingredient in Mounjaro, not only regain weight but also experience a reversal of other health benefits they had achieved while taking the medication.
The study, which involved over 300 participants with obesity or overweight issues, revealed that within a year of stopping tirzepatide, nearly three-quarters of those who had lost at least 10% of their body weight initially regained 25% or more of what they had lost. The researchers also found that the extent of weight regain was correlated with the degree to which other health markers – such as blood pressure, waist circumference, and levels of "bad" cholesterol – reverted to baseline values.
Experts say this is not a surprising finding, given the well-established link between excess weight and elevated blood pressure, impaired glucose control, and other cardiometabolic risks. Dr. Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow, noted that when weight loss achieved through medication is regained, these risk factors tend to increase in proportion to the speed and extent of weight regain.
The study's findings have significant implications for the long-term management of obesity and related health conditions. While Mounjaro has shown promise in helping people lose an average of 20% of their body weight over 72 weeks, its effects are short-lived once use is discontinued. Dr. Jane Ogden, an emeritus professor at the University of Surrey, warned that relying on weight-loss medications without developing sustainable lifestyle habits can lead to a reversal of health benefits.
The study's authors emphasized the importance of long-term maintenance of weight reduction through a combination of lifestyle intervention and medication management to sustain cardiometabolic benefits and improved health-related quality of life.
i mean, come on, if you're gonna take meds to help you get fit, don't be all like "oh well, I'll just go back to eating pizza and beer" 
at least be consistent in your suffering... or something 
seriously though, what's up with that? is it too hard for ppl to stick to lifestyle changes? can we please get some guidance on this kinda thing? like, a how-to-on-reversing-weight-regain guide or something 
. i mean, we all know weight loss meds aren't forever solutions, but it's wild how quickly they lose their effectiveness. like, what's the point of even trying if you're just gonna regain everything once you stop? 
and to think we're relying on these meds without teaching people sustainable lifestyle habits... that's just setting them up for failure 
. doctors need to be more realistic about how these meds work and what they can (and can't) do long-term. it's not about the medication, it's about the real changes we need to make in our lives 
" I mean, we're all about the quick fix, right? Mounjaro was supposed to be that magic pill that helped us lose weight and feel good. But now it seems like as soon as we stop taking it, our bodies are just like "oh wait, let's go back to being fat and sluggish 
". It's like we forget the hard work we put in when we were taking it. My mom used to say that if you want to lose weight, you gotta stick to a healthy diet and exercise routine - not just rely on some magic pill. And now I'm like "yeah, she was right all along 
". This study just confirms what my grandma used to tell me: "you can't outsmart your body, you have to take care of it" 
.
Like, I'm not saying medications don't have their place, but we gotta be smart about it and not rely on them alone. We should actually care about our own health for once! 
anyone else have experience with this? what's the deal with weight loss meds, do they really work in the long run? or is that just how it goes? like, why can't we just find a permanent solution? 
. I think we need to focus on making lifestyle changes, you know, eat better and exercise more, rather than relying on meds that only work for a little while 
.
anyway back to mounjaro its kinda sad that people get used to losing weight and then just lose everything again guess we need 2 stick 2 exercise & diet plans 
I'm not surprised, tbh 
. They might help you shed some pounds initially, but they're not a permanent fix 
. And now we know that once you stop using them, all the progress you made can just slip right back into your old habits 
if u r gonna stop taking it, u should probably have a plan in place 2 prevent regaining weight lol some ppl might be good at sticking 2 themselves but honestly it's hard 
i feel like i was living under a rock lol. so it turns out mounjaro isn't as magic as we thought? like, yeah no surprise there. docs have been saying that for ages. but still kinda scary if you're counting on the meds to help you lose weight and then... nada. just back to square one 
what if we're just being kept in a cycle of dependency? and what's with the 'sustainable lifestyle habits' thingy? sounds like marketing fluff to me... shouldn't be so hard to find info on how to keep weight off for real, right? 
... I know some people rely on these meds for quick weight loss, but the reality is that it's just not a sustainable solution, you feel? The study shows that once they stop taking it, they start gaining weight and losing all those health benefits they got while using it. It's like they're right back to square one! I mean, I've heard of people trying fad diets or extreme exercise routines that don't work out in the long run... but at least with a fad diet you know it's temporary. With Mounjaro, it seems like people are stuck in this cycle of weight gain and lost health benefits, which is just heartbreaking 
. And it's not just about the weight, either - it's like their whole health is going downhill again 
. We need to figure out ways to make sustainable lifestyle changes stick 
, or else we'll be back to square one. Can't have people relying on meds forever, gotta think about long-term solutions 
. i think this study is super important because it highlights how we need to be more sustainable with our lifestyle habits & meds 
. no one wants to go back to where they started after all that progress