Small amounts of lithium found in drinking water may be linked to an increased risk of autism spectrum disorder (ASD) in children, according to a new study published in JAMA Pediatrics. Researchers from Denmark analyzed data from 8,842 cases of ASD and 43,864 participants who did not have ASD, finding that the concentration of lithium in public waterworks was associated with a modest increase in ASD diagnosis.
The study found that pregnant women exposed to higher levels of lithium in drinking water were more likely to give birth to children with autism. Specifically, those with the second and third highest exposure had a 24% to 26% increased risk of ASD diagnosed in children, while those with the highest exposure had a 46% higher risk than those at the lowest level.
However, experts caution that this association does not prove a direct link between lithium exposure and autism. Dr. Beate Ritz, a study co-author, noted that further research is needed to confirm these findings and rule out other factors that may contribute to the association.
"It's an interesting association, but causation is definitely not proven," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "We have to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
The study highlights the complexity of autism research, where environmental factors such as air pollution and pesticides have been suggested as potential causes, but none of them has been proven directly linked to the disorder.
Dr. Wiznitzer emphasized that proving causality is challenging due to the numerous environmental stressors we are exposed to on a daily basis. "We need to figure out how to safely navigate these stressors," he said.
The findings also raise questions about public health policy regarding lithium levels in drinking water. Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School, noted that the wisdom of Solomon would be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population.
While the study's results are intriguing, more research is needed to confirm these findings and determine whether small amounts of lithium in drinking water pose a significant risk to children with autism.
The study found that pregnant women exposed to higher levels of lithium in drinking water were more likely to give birth to children with autism. Specifically, those with the second and third highest exposure had a 24% to 26% increased risk of ASD diagnosed in children, while those with the highest exposure had a 46% higher risk than those at the lowest level.
However, experts caution that this association does not prove a direct link between lithium exposure and autism. Dr. Beate Ritz, a study co-author, noted that further research is needed to confirm these findings and rule out other factors that may contribute to the association.
"It's an interesting association, but causation is definitely not proven," said Dr. Max Wiznitzer, director of the Rainbow Autism Center at University Hospitals Rainbow Babies and Children's Hospital in Cleveland. "We have to see if there's a viable and biologically plausible mechanism by which a small amount of lithium in the water supply can somehow do this."
The study highlights the complexity of autism research, where environmental factors such as air pollution and pesticides have been suggested as potential causes, but none of them has been proven directly linked to the disorder.
Dr. Wiznitzer emphasized that proving causality is challenging due to the numerous environmental stressors we are exposed to on a daily basis. "We need to figure out how to safely navigate these stressors," he said.
The findings also raise questions about public health policy regarding lithium levels in drinking water. Dr. David C. Bellinger, a professor of neurology and psychology at Harvard Medical School, noted that the wisdom of Solomon would be required to develop guidelines for lithium in drinking water that are maximally protective of the entire population.
While the study's results are intriguing, more research is needed to confirm these findings and determine whether small amounts of lithium in drinking water pose a significant risk to children with autism.